Business & Industry (Specialty) in San Antonio
A metro's real, distinctive industry presence is a genuine reason someone relocates for work. San Antonio's is built around a national-security cyber cluster, one of the country's largest military installations, and a major bioscience corridor.
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NSA Texas (Texas Cryptologic Center)
Based at JBSA-Lackland's Medina Annex with roughly 3,000 employees — NSA Texas describes San Antonio as home to "the largest contingent of cyber assets in the United States, outside of the Washington, D.C. region," the basis of the city's "Cyber City, USA" reputation.
16th Air Force (Air Forces Cyber)
Roughly 45,000 Total Force Airmen across 123 global locations — serves as the Air Force component to U.S. Cyber Command, with a defense technology cluster of at least 80 cybersecurity/defense-tech businesses around it per the San Antonio Economic Development Foundation.
USAA
An insurance and financial-services company headquartered in San Antonio since its founding in 1922 — roughly 37,000 employees and $211.6 billion in total assets.
Joint Base San Antonio (JBSA)
Supports 250,000+ personnel and houses the DoD's largest hospital and its only Level I trauma center. The city holds the U.S.-registered trademark "Military City, USA®" (2017).
South Texas Medical Center
45+ institutions and 12 hospitals with 4,200+ patient beds, anchored by UT Health San Antonio, Texas Biomedical Research Institute, Southwest Research Institute, and Brooke Army Medical Center.
Port San Antonio
Generates $20 billion in annual economic output and supports 83,800 jobs statewide (2024 figures). Home to StandardAero, one of the world's largest aircraft-engine overhaul facilities, and Boeing's largest global aircraft maintenance and sustainment operation.