Business & Industry (Specialty) in Indianapolis

A metro's real, distinctive industry presence is a genuine reason someone relocates for work. Indianapolis's is built around a trillion-dollar pharmaceutical headquarters, two more Fortune 500 headquarters, and one of the country's largest cargo-airport hubs.

Every item on this page clears one bar: not commonplace, not everywhere. These are real, named resources with their actual verified designation or certification — not a generic "has a hospital" or "has a gym" list. We left out anything we couldn't independently verify or that didn't clearly clear that bar, the same honesty rule used throughout this site — a shorter, accurate list beats a padded one.

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Fortune 500 #65 — Most Valuable Pharma Company in the World

Eli Lilly and Company

Headquartered in Indianapolis, Lilly ranked #65 on the 2026 Fortune 500 ($65.2B revenue), employs roughly 50,000 people, and in November 2025 became the first healthcare company ever to reach a $1 trillion market capitalization.

Source: Wikipedia (Eli Lilly and Company)

Fortune 500 #17 — Highest-Ranked Company Headquartered in Indiana

Elevance Health

Headquartered in Indianapolis, Elevance Health (formerly Anthem) ranked #17 on the 2026 Fortune 500 with $199.1 billion in revenue and roughly 104,200 employees -- the highest-ranked company headquartered in Indiana.

Source: Indiana Hub — Fortune 500 in Indiana

Largest Shopping Mall/REIT Owner in the U.S.

Simon Property Group

Headquartered in Indianapolis, Simon is the largest owner of shopping malls in the United States, with interests in 235 properties as of mid-2026 and $5.96 billion in 2024 revenue, repeatedly named Fortune's "Most Admired" real estate company.

Source: Wikipedia (Simon Property Group)

Fortune 500 — Global Crop-Protection Headquarters

Corteva

Following Corteva's 2026 corporate split, the crop-protection business retains the Corteva name and its global headquarters in Indianapolis, anchoring Indiana's broader agbioscience sector, which contributes over $82 billion to the state economy.

Source: AgriNews

2nd-Largest FedEx Hub in the World

FedEx Express Indianapolis Hub

Opened in 1988 at Indianapolis International Airport, FedEx's second-largest hub worldwide employs nearly 4,000 team members with a sort capacity of 99,000 packages per hour, anchoring Indianapolis International's ranking as the #8 cargo airport in the U.S.

Source: FedEx